老年神经衰弱患者血清皮质醇和超敏C-反应蛋白变化的检验研究

Test study on changes of serum cortisol and hypersensitivity C-reactive protein in elderly patients with neurasthenia

目的探讨老年神经衰弱患者血清皮质醇和超敏C-反应蛋白(hs-CRP)的检验意义。方法选取该院2012年1月至2015年6月收治的老年神经衰弱患者160例作为研究对象(观察组),并选取该院进行体检的健康老年患者160例作为对照组,比较两组研究对象血清中脑源性神经生长因子(BDNF)、皮质醇(CORT)和hs-CRP的差异。并根据汉密尔顿焦虑量表(HAMD)将研究对象分为明显焦虑组和焦虑组,比较两组患者体内BDNF、CORT和hs-CRP的差异;同时测定达到理想治疗效果的神经衰弱患者血清中BDNF、CORT和hs-CRP水平,并与治疗前进行统计学比较。结果观察组患者BDNF和CORT水平显著低于对照组,且hs-CRP显著高于对照组;明显焦虑组患者BDNF和CORT水平显著低于焦虑,且hs-CRP显著高于焦虑组;治疗结果也表明,取得理想治疗效果的患者BDNF和CORT水平与治疗前相比显著增高;而hs-CRP水平显著下降。结论 BDNF、CORT和hs-CRP与神经衰弱的发生以及严重程度有着显著的相关性,临床实际工作中值得重点予以关注。

Objective To investigate the significance of serum cortisol and high-sensitivity C-reactive protein（hs-CRP）test in elderly patients with neurasthenia.Methods A total of 160 elderly patients with neurasthenia in our hospital from January 2012 to June 2015 were selected as the research subjects（observation group）and 160 individuals undergoing the physical examination as the control group.The differences of serum BDNF,CORT and hs-CRP levels were compared between the two groups.The patients were divided into the obvious anxiety group and anxiety group according to the Hamilton Anxiety Scale（HAMD）.The differences of serum BDNF,CORT and hs-CRP levels were compared between these two groups;meanwhile serum BDNF,CORT and hs-CRP levels after treatment in the patients with ideal curative effect were detected and the detection results were statistically compared with those before treatment.Results The BDNF and CORT levels in the observation group were significantly lower than those in the control group,while the hs-CRP level was significantly higher than that in the control group;the BDNF and CORT levels in the obvious anxiety group were significantly lower than those in the anxiety group,while the hs-CRP level was significantly higher than that in the anxiety group;the treatment outcome also showed that the BDNF and CORT levels after treatment in the patients obtaining the ideal effect were significantly increased compared with the pre-treatment levels;while the hs-CRP level was significantly decreased.Conclusion BDNF,CORT and hs-CRP are significantly correlated with neurasthenia occurrence and its severity,which deserves to pay attention to in clinical practice.