不同剂量辛伐他汀治疗脑梗死的疗效和药理作用

Efficacy and Pharmacological Effects of Different Doses of Simvastatin in the Treatment of Cerebral Infarction

目的分析不同剂量辛伐他汀治疗脑梗死的疗效和药理作用。方法选择脑梗死患者80例,随机分为对照组和实验组各40例,全部患者均实施临床常规治疗,对照组给予低剂量(20 mg/d)辛伐他汀治疗,对照组给予大剂量(40mg/d)辛伐他汀治疗。结果治疗前两组患者的DNS评分比较差异无统计学(P>0.05),治疗后实验组患者的DNS评分显著低于对照组患者(P<0.05);实验组总有效率分别为95.0%(38/40),对照组为80.0%(32/40),两者比较差异有统计学意义(P<0.05)。在不良反应发生率方面,两组患者比较差异无统计学意义(P>0.05)。结论脑梗塞患者进行治疗时,给予大剂量(40 mg/d)辛伐他汀治疗,患者的神经功能缺损程度有效降低,在提高疗效的同时不会显著提高不良反应发生几率,具有临床推广和应用价值。

Objective To analyze the therapeutic effect and pharmacological effects of different doses of simvastatin in the treatment of cerebral infarction. Methods 80 cases of cerebral infarction patients were randomly divided into two group： 40 cases in control group and 40 cases in the experimental group. All patients were treated with clinical routine treatment. Low dose （20 rag/d） of simvastatin was given to the control group, while high dose （40 rag/d） of simvastatin was given to the experiment group. Results There was no significant difference in the DNS score between two groups before treatment （ P 〉 0.05 ）. After treatment, the DNS score was significantly lower in the experimental group than that of the control group （ P 〈 0.05 ）. The total efficiency of the experimental group was 95.0% （38/40）, while that of the control group was 80.0% （32/40） （P 〈 0.05 ）. Regarding the incidence of adverse reactions, there was no significant differences between the two groups （P 〉 0.05）. Conclusion In the treatment of patients with cerebral infarction, high dose of （40 mg/d） simvastatin could effectively reduce the patient＇s neurologic impairment, improve curative effect at the same time without improving the adverse reaction incidence, which has much clinical popularization and application value.