四君子汤加减内服、外洗联合西医乳膏外擦辨治湿热型银屑病的临床研究

Clinical observation on treating Damp-hot type psoriasis with the oral administration and external washing of Sijunzi decoction and the application of western medicine cream

目的:观察用四君子汤加味内服、外洗联合乳膏外擦辨治湿热型银屑病的临床疗效。方法:将就诊于我院的94例湿热型银屑病患者随机分为对照组和治疗组各47例。对照组患者给予维A酸乳膏、卡泊三醇乳膏外擦;治疗组患者则加用四君子汤加减内服、外洗治之,连续用药4周。观察患者临床症状改善,对证候给予评分,评价临床治愈的有效率;用银屑病皮损程度评分(PASI)评估患者治疗前后皮损程度,对治疗前后的生活质量进行评估。结果:治疗组患者的总有效率显著优于对照组(P<0.05);治疗组患者的瘙痒、红斑、鳞屑、乏力困倦等临床症状改善程度明显优于对照组患者,证候积分下降程度较对照组更显著,差异具有统计学意义(P<0.05);治疗组患者的PASI积分下降程度与对照组患者相比更为突出,差异具有统计学意义(P<0.05);治疗组患者的生活质量改善较对照组患者更为明显,其DLQI评分下降程度大于对照组患者,组间比较差异有统计学意义(P<0.05)。结论:四君子汤加味内服、外洗联合乳膏外擦治疗湿热型银屑病疗效确切,利于改善患者的临床症状,减轻皮损程度,提高患者的生活质量,值得临床运用。

Objective：To investigate the clinical efficacy of treating damp-hot type psoriasis with the oral administration and external washing of Sijunzi decoction and the application of western medicine cream.Methods：94cases with damp-hot type psoriasis treated in our hospital were randomly divided into control group and treatment group and 47 cases in each group.Patients in the control group were treated with vitamin A acid cream and calcipotriol ointment;while patients in the treatment group were treated with 4weeks＇ oral administration and external washing of Sijunzi decoction.The research was aim at observing the improvement of main clinical symptom,evaluating the clinical symptom and the efficiency;the severity of psoriasis before and after treatment was assessed by PASI,and the quality of life before and after treatment was estimated.Results：The total effective rate of patients in treatment group was significantly better than that of the control group（P〈0.05）;The pruritus,erythema,scale,drowsiness and weak and other clinical symptoms of patients in treatment group had a better improvement degree than the control group,and the syndrome integral of patients in treatment group decreased more significantly than the control group,the difference was statistically significant（P〈0.05）;The degree of decline of PASI score for the patients in the observation group was more significantly than that in the control group,the difference was significant（P〈0.05）;The quality of life of the patients in treatment group improved more significantly than that in the control group,the DLQI score decreased more than the control group,there were significant differences between the groups（P〈0.05）.Conclusion：The clinical efficacy of treating damp-hot type psoriasis with the oral administration and external washing of Sijunzi decoction and the application of western medicine cream is effective,it can improve the clinical symptoms of the patients,reduce the extent of lesions,improve patients＇ quality of life,and it is worthy of clinical application.