丹蛭胶囊治疗阿司匹林抵抗心血瘀阻型冠心病心绞痛临床观察

Effective observation on treating Aspirin resistance in patients with angina pectois of the Xinxue Yuzu type with the Danzhi capsule

目的:探讨丹蛭胶囊干预阿司匹林抵抗心血瘀阻型冠心病心绞痛的临床疗效。方法:将筛查出的100例阿司匹林抵抗患者分为两组。对照组给予阿司匹林肠溶片,治疗组给予阿司匹林肠溶片加服丹蛭胶囊。比较两组患者2周后的血小板聚集率实验指标、心绞痛临床疗效、心绞痛持续时间、中医临床疗效及心电图疗效。结果:治疗组在干预以花生四烯酸(AA)为诱导剂检测血小板聚集的实验研究中优于对照组(P<0.05);治疗组在改善心绞痛疗效方面优于对照组(P<0.05);治疗组在改善心绞痛持续时间方面优于对照组(P<0.05);在中医证候疗效方面治疗组优于对照组(P<0.05);在心电图疗效评价比较中两组无明显差异。结论:丹蛭胶囊能够缓解阿司匹林抵抗,加强抗血小板聚集作用,减少心绞痛次数及缩短持续时间。

Objective： To investigate clinical effcacy of the Danzhi capsule on Aspirin resistance in patients with angina pectoris of the Xinxue Yuzu type. Methods： 100 patients were randomly divided into two groups. The control group was given the Aspirin; and the treatment group was given the Danzhi capsule more. In 2 weeks, experimental index of platelet aggregation rate, the clinical effcacy of angina pectoris, duration of angina, the clinical effcacy of TCM and the effcacy of ECG in two groups were compared. Results： All indexes in the treatment group were better （P〈0.05）. But there is no signiifcant difference of the ECG effcacy in two groups. Conclusion： The Danzhi capsule on Aspirin resistance in patients with angina pectoris of the Xinxue Yuzu type could relieve Aspirin resistance, increase anti-platelet aggregation, and reduce the number of angina and the duration.