芩梅颗粒联合复方锌维乳膏治疗寻常型银屑病的临床疗效评价

Evaluation of clinical effect of Qinmei Granules combined with Compound Xinwei Cream on psoriasis vulgaris

目的对芩梅颗粒(黄芩、青黛、当归等)治疗寻常性银屑病的临床疗效和安全性进行评价。方法 80例寻常性银屑病患者随机分成对照组和试验组,每组40例,对照组外用复方锌维乳膏,试验组在此基础上同时口服芩梅颗粒,每日2次,每次12 g,疗程均为12周。比较两组治疗前后银屑病皮损面积和严重程度指数(PASI)、皮肤病生活质量指数(DLQI)、医生对病情的整体评分(PGA)、目视模拟标尺对病情的整体评分(VAS)。结果经过12周治疗后,两组PASI、DLQI、PGA和VAS指标较治疗前明显降低(P<0.05),治疗组比对照组治疗效果显著(P<0.05),未见严重不良反应。结论芩梅颗粒治疗寻常性银屑病安全有效。

AIM To evaluate the climical effect and safety of Qinmei Granules（ Scutellariae Radix,Indigo naturalis,Angelicae sinensis Radix,etc.） on the treatment of psoriasis vulgaris. METHODS Eighty patients with psorias vulgaris were randomly divided into control group and experimental group,40 cases in each group. The control group was given external Compound Xinwei Cream,which experimental group was given Qinmei Granules and Compound Xinwei Cream at the same time,twice a day and 12 g each time. Total twelve weeks were considered as a course. Psoriasis area and severity index（ PASI）,dermatology life quality index（ DLQI）,physician global assessment（ PGA） and visual analogue scale（ VAS） were compared between the two groups before and after treatment. RESULTS After twelve weeks＇ treatment,PASI,DLQI,PGA and VAS in the two groups had significant differences（ P 〈 0. 05）. The experimental group had better treatment effect than the control group（ P〈 0. 05）. Both groups showed no obvious adverse reactions. CONCLUSION Qinmei Granules is safe and effective in treating psoriasis vulgaris.