中国北方人群多发性硬化的临床与MRI特点研究

Clinical features and MRI features of multiple sclerosis in people in north China

目的回顾性分析中国北方人群MS的临床特点与MRI影像表现。方法回顾性分析117例MS患者临床资料,分为视神经脊髓组（OSMS）42例和经典多发性硬化组（CMS）75例。比较2组患者临床特点、MRI表现和EDSS评分。结果OSMS患者脑脊液中白细胞数量显著高于CSM患者（P〈0.05）。MRI显示2组脊髓病灶数量差异有统计学意义（P〈0.05）。MRI显示CMS脊髓病灶为沿着脊髓长轴分布,且脊髓肿胀。OSMS脊髓呈萎缩状态。5年EDSS评分显示OSMS显著高于CMS（P〈0.05）。1~5年OSMS复发率明显高于CMS患者。结论 OSMS发病率高于西方患者。

Objective To analyze clinical characteristics of MS and MRI manifestation in people in north China. Methods Clinical materials of 117 patients with MS were analyzed retrospectively,and they were divided into optic nerve spinal multiple sclerosis group（ OSMS,n = 42） and classical multiple sclerosis group（ CMS,n = 75）. Clinical characteristics,MRI manifestation and expanded disability status scale（ EDSS） score were compared between the two groups. Results White blood cells of OSMS patients were significantly higher than that of CMS patients（ P〈0. 05）. The MRI showed that there was significant difference in number of spinal cord lesions between two groups（ P〈0. 05）. MRI showed that CMS spinal cord lesions were distributed along the long axis of the spinal cord. Spinal cord in patients with OSMS atrophied. The EDSS score in 5 years was significantly higher in patients with OSMS than patients with CMS（ P〈0. 05）. Relapse rates of patients with OSMS from first to fifth year were significantly higher than patients with CMS. Conclusion OSMS shows a higher incidence rate in patients in north China than patients in the western countries.