半夏泻心汤加减治疗脓毒症胃肠功能障碍的临床观察

Clinical Observation of Banxia Xiexin Decoction on Gastrointestinal Dysfunction of Sepsis

目的观察半夏泻心汤加减治疗脓毒症胃肠功能障碍的临床疗效。方法将80例患者按照随机数字表法分为两组,各40例。对照组给予常规治疗,观察组在常规治疗基础上加服半夏泻心汤加减。两组服药14 d后对患者临床症状、实验室检查指标变化进行对比。结果观察组总有效率为77.50%,高于对照组的55.00%(P<0.05)。治疗组胃肠功能障碍评分、肠内营养耐受率、中医症状改善率、APACHEⅡ评分及血清白细胞计数、血清降钙素原水平均优于对照组(P<0.05)。结论半夏泻心汤加减可减轻脓毒症患者胃肠功能障碍症状,提高肠内营养的利用率,提高临床疗效。

Objective： To observe the clinical application effect of Banxia Xiexin Decoction on gastrointestinal dysfunction of sepsis. Methods： 80 patients were randomly divided into the control group and the observation group,40 cases in each. The control group was given conventional treatment while the observation group on the basis of that was added Banxia Xiexin Decoction. After 14 days of treatment ,clinical symptoms and laboratory in dexes were compared. Results： The observation group has a higher treatment effective rate（77.50% vs 55.00%, P 〈 0.05）,lower Gastrointestinal dysfunction scores, higher EN tolerance rate, higher TCM symptoms improvement rate, lower APACHE Ⅱ scores, lower WBC count and lower PCT count （P 〈 0.05 ）. Conclusion： Banxia Xiexin Decoction can reduce gastrointestinal dysfunction of sepsis ,and improve the utilization rate of enteral nutrition and improve clinical efficacy.