美托洛尔与卡维地洛治疗慢性心力衰竭的临床效果比较

The comparison of clinical effect of metoprolol and carvedilol in the treatment of chronic heart failure

目的:比较美托洛尔与卡维地洛治疗慢性心力衰竭的临床效果。方法:将168例慢性心力衰竭患者随机分为观察组和对照组,每组84例,两组患者均给予相同的常规治疗,对照组加用美托洛尔,观察组加用卡维地洛。结果:观察组患者的显效率和总有效率均高于对照组(P<0.05);两组患者的不良反应发生率比较,差异无统计学意义(P>0.05);治疗后,观察组患者血位速度峰值比、左室射血分段、左室收缩末期内径、左室舒张末期内径的改善程度均优于对照组(P<0.01)。结论:应用卡维地洛治疗慢性心力衰竭,能在保证安全性的前提下,发挥更好的治疗效果,值得临床推广。

Objective： To compare the clinical effect of metoprolol and carvedilol in the treatment of chronic heart failure （ CHF） .Methods：168 cases of CHF were randomly divided into the observation group and the control group .The two groups were given the same routine therapy , the control group added with metoprolol, and the observation group added with carvedilol.Results：The efficiency rate and total effective rate in the ob-servation group were significantly higher than that in the control group （all P 〈0.05）, and there was no significant difference in the incidence of adverse reaction in the two groups.The ameliorating degree of E/A, LVEF, LVES and LVED in the observation group was significantly higher than that in the control group （ P 〈0.01）.Conclusion：Carvedilol in the treatment of CHF is of better curative effect on the basis of safety guarantee , and it deserves considering in clinical work.