类风湿关节炎患者血清肿瘤标志物CA199及CA153检测及临床意义

Rheumatoid Arthritis Patients with Serum Tumor Marker CA199 and CA153 Detection and Clinical Significance

目的探讨类风湿关节炎(RA)患者血清CA153及CA199检测的临床意义。方法随机选取本院收治的RA患者46例作为RA组,另选取同期体检健康人46例作为对照组,对两组受试对象进行血清CA153及CA199水平测定,并对其进行分析。结果 RA组患者的CA199、CA153水平均明显高于对照组,差异具有显著性(P<0.05)。结论 RA患者普遍存在血清肿瘤标志物水平上升现象,且CA153水平同患者机体急性时相反应物CRP、ESR呈明显正相关,可作为RA患者病情评估的重要依据。

Objective To study the clinical significance of serum CA153 and CA199 in patients with rheumatoid arthritis（RA）. Methods 46 cases of RA patients were randomly selected in our hospital and considered them as RA group,46 cases of healthy people were selected as the same period as RA group and considered them as the control group, serum CA153 and CA199 levels of two groups were measured and analyzed. ResultsCA199, CA153 level of RA group were significantly higher than the control group, the difference was significant（P〈0.05）. Conclusion RA patients the prevalence of serum tumor marker levels rise phenomenon, and CA153 levels in patients with acute body phase reactant CRP, ESR is positively correlated, as RA patient＇s condition to assess the important basis.