噻托溴铵治疗中重度稳定期慢性阻塞性肺疾病疗效观察

Efficacy of Tiotropium Bromide in the Treatment of Moderate and Severe Chronic Obstructive Pulmonary Disease

目的观察噻托溴铵治疗中重度稳定期慢性阻塞性肺疾病的疗效。方法将我院收治的86例中重度稳定期慢性阻塞性肺疾病患者作为研究对象,随机分组,各43例。常规组应用异丙托溴铵治疗,研究组应用噻托溴铵治疗。比较两组患者治疗后呼吸困难及肺功能改善情况。结果常规组呼吸困难改善总有效率69.8%低于研究组95.3%,两组差异显著(P<0.05);常规组肺功能改善有效率81.4%低于研究组97.7%,两组差异显著(P<0.05)。结论中重度稳定期慢性阻塞性肺疾病患者应用噻托溴铵,取得临床疗效良好,可显著改善肺功能及临床症状。

Objective To observe the efficacy of tiotropium bromide in the treatment of moderate and severe chronic obstructive pulmonary disease. Methods 86 cases of moderate and severe chronic obstructive pulmonary disease patients admitted to our hospital and as the research objects, all of them were randomly divided into two groups, and 43 cases in each group. The conventional group was treated with ipratropium bromide, and the study group was treated with tiotropium bromide. The dyspnea and pulmonary function improvement situation of two groups after treatment were compared. Results The effective rate of dyspnea in the conventional group was 69.8%, which was lower than that in the study group 95.3%, the difference between the two groups was significant（P〈0.05）;The effective rate of improvement of lung function in the conventional group was 81.4%,which was lower than that in the study group 97.7%, the difference between the two groups was significant（P〈0.05）. Conclusion Tiotropium bromide in the treatment of moderate and severe chronic obstructive pulmonary disease patients can achieve good clinical efficacy, can significantly improve the pulmonary function and clinical symptoms.