艾司西酞普兰治疗老年抑郁症的效果及其对生活质量的影响

Curative effects of escitalopram in the treatment of elderly depression and its effects on life quality

目的了解艾司西酞普兰治疗老年抑郁症的有效性和对生活质量的影响。方法选择2010年10月~2015年10月门诊和住院的抑郁症患者,将其随机分为艾司西酞普兰组（艾司组）和西酞普兰组,各30例,分别给予艾司西酞普兰和西酞普兰治疗,于治疗前,治疗第1周末、2周末、4周末、8周末、12周末,采用Hamilton抑郁量表（HAMD）评定疗效,采用生活素质综合评定问卷（GQOLI-74）评估其生活质量,并观察不良反应。结果治疗前两组HAMD评分比较差异无统计学意义（P〉0.05）;在治疗后第1周末至12周末,两组的HAMD评分逐渐降低,与治疗前比较差异有统计学意义（P〈0.05）;在治疗的12周末,艾司组HAMD评分较西酞普兰组下降更多,差异有统计学意义（P〈0.05）;与治疗前比较,在治疗12周末,两组在躯体功能、心理功能和社会功能方面均显著改善（P〈0.01）;在治疗12周末,艾司组躯体功能和社会功能的改善优于西酞普兰组（P〈0.01）;两组不良反应均轻微。结论艾司西酞普兰有助于提高老年抑郁症的长期疗效,改善其生活质量。

Objective To understand the effectiveness of escitalopram in the treatment of elderly depression and its effects on life quality.Methods 60 outpatients and inpatients with elderly depression from October 2010 to October 2015 were randomly assigned to two groups,with 30 patients in each group.The two groups were given the treatment of escitalopram and citalopram respectively.HAMD was applied before the treatment,at the end of the first week,second week,fourth week,eighth week and twelfth week after the treatment to evaluate the curative effects,GQOLI-74 was applied to evaluate patients′ life quality,and adverse reactions were observed.Results The differences of total scores of HAMD before the treatment in escitalpram group and citalpram group were not statistically significant（P〉0.05）;At the end of the first week until the twelfth week after the treatment,the total score of HAMD in both groups was gradually reduced respectively,and the difference compared with that before the treatment was statistically significant（P〈0.05）;At the end of the twelfth week,compared with citalpram group,the total score of HAMD in escitalpram group was reduced more greatly,and the difference between the two groups was statistically significant（P〈0.05）;Compared with the situation before the treatment,at the end of the twelfth week,physical function,mental function and social function in both groups was significantly improved respectively（P〈0.01）;At the end of the twelfth week,the improvement of physical function and social function in escitalpram group was better than that in citalpram group（P〈0.01）;The adverse reactions in both groups were slight.Conclusion Escitalpram is helpful for enhancing long-term curative effects and improving life quality in patients with elderly depression.