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生物标记物在急性肾损伤应用的新进展 被引量:4

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摘要 急性肾损伤是常见的急危重症,在普通住院患者中AKI的患病率为3%~5%;而重症监护病房中更是高达30%~50%,引起长期或短期死亡率增加,并带来高额的经济负担[1,2]。急性肾损伤的预防和治疗主要依赖于优化血流动力学和避免使用肾毒性药物,但在过去几十年中,特殊的预防措施、治疗策略或者药物并没有带来显著的成效[3]。ICU中重症患者AKI诊断的延迟,对于死亡率和慢性肾脏病患病率的增加[4,5],
出处 《中国中西医结合肾病杂志》 2016年第5期449-452,共4页 Chinese Journal of Integrated Traditional and Western Nephrology
基金 北京市科委基金资助项目(No.Z131107002213011)
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  • 1Nisula S, Kaukonen KM, Vaara ST, et al. Incidence, risk factors and 90 - day mortality of patients with acute kidney injury in Finnish intensive care units: the finnaki study. Intensive Care Med,2013,39(3) :420-428.
  • 2Kerr M, Bedford M, Matthews B, et al. The economic impact of a- cute kidney injury in England. Nephrol Dial Transpl, 2014,29 (7) :1362 - 1368.
  • 3Kellum JA, Lameire N, KDIGO AKI Guideline Work Group. Di- agnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1 ). Crit Care,2013,17( 1 ) :204.
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  • 5Ishani A, Xue JL, Himmelfarb J, et al. Acute kidney injury in- creases risk of ESRD among elderly. J Am Soc Nephrol,2009,20 ( 1 ) : 223 - 228.
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  • 9Wheeler DS, Devarajan P, Ma Q, et al. Serum neutrophil gelati- nase - associated fipoealin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med, 2008.36(4) , 1297 - 1303.
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二级参考文献4

  • 1Cruz ND,Kicci Z,Ronco C.Clinical review:RIFLE and AKIN-time for reappraisal.Crit Care,2009,13(3):211.
  • 2Mehta KL,Kellun JA,Shah SV,et al.Acute Kidney Injury Network:report of an initiative to improve outcomes to improve acute kidney injury.Critical Care,2007,11(2):R31.
  • 3National Kidney Foundation.K/DOQI Clinical Practice Guidelines for Chronic Kidney Disease:Evaluation.Classification and Stratification.Am J Kidney.Dis,2002,39(Suppl 1):S1-S266.
  • 4Parikh CR,Abraham E,Ancukiewicz M,et al.Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unite.J Am Soc Nephrol,2005,16(10):3046-3052.

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