P57^(kip2)和AQP1在肺腺癌中的表达及其临床意义

Expression of aquaporin- 1 and P57^(kip2) in pulmonary adenocarcinoma and their clinical significance

目的探讨P57^(kip2)和AQP1在肺腺癌组织中的表达特点及与肿瘤转移的关系。方法采用免疫组织化学方法(SP法)检测60例肺腺癌患者手术切除标本癌组织及癌旁正常组织中P57^(kip2)和AQP1的表达水平,分析二者的表达与肺腺癌临床病理特征的关系。结果在肺腺癌组织中P57^(kip2)阳性表达率明显低于正常肺组织(P<0.05),AQP1阳性表达率明显高于正常肺组织(P<0.05);有淋巴结转移者肺腺癌组织中P57^(kip2)阳性表达率明显低于无淋巴结转移者(P<0.05),AQP1阳性表达率明显高于无淋巴结转移者(P<0.05)。P57^(kip2)和AQP1在肺腺癌中的表达呈负相关(r=-0.47,P<0.05)。结论 P57^(kip2)和AQP1可能与肺腺癌的发生发展有关,二者联合检测可作为评估肺腺癌转移与预后的指标。

Objective It is to investigate the expression characteristics of P57kip2 and aquaporin- 1 （AQP1） in adenocar- cinoma of lung and those correlation with tumor metastasis. Methods Immunohistochemical method （ SP method） was used to detect the expression of P57kip2 and AQP1 in 60 cases of adenocarcinoma tissue and the normal tissue of the adenocarcinoma patients. The relationship between the expression of P57kip2 , AQP1 and the clinicopathological characteristics of lung adenocar- cinoma was analyzed. Results The expression positive rate of P57kip2 in adenocarcinoma tissue was significantly lower than that in normal tissue, and the expression positive rate of AQP1 in adenocarcinoma tissue was significantly higher than that in normal tissue, there were significant difference （all P 〈 0.05）. The expression positive rate of P57kip2 in adenocarcinoma tissue with lymph node metastasis was significantly lower than that without lymph node metastasis, and the expression positive rate of AQP1 in adenocarcinoma tissue with lymph node metastasis was significantly higher than that without lymph node metastasis, there were significant difference （ all P 〈 0.05 ）. There was a negative correlation between the expression of P57kip2 and AQP1 in adenocarcinoma tissue （ r = - 0.47, P 〈 0.05）. Conclusion The low express of P57kip2 and high express of AQP1 may be associated with the genesis and the development of human adenocarcinoma of lung. The combined detection of AQP1 and P57kip2 may be used in assessing the metastasis and predicting the clinical prognosis of adenocarcinoma.