防惊散防治小儿热性惊厥效果研究

Effect of Fangjingsan in Children With Febrile Seizures

目的观察防惊散对小儿热性惊厥发作的防治效果。方法将120例热性惊厥患儿随机分成三组,每组各40例。治疗组：防惊散每日一剂,分早晚开水冲服,连用30 d后停药。感染期间仅予常规治疗（抗感染、解热、对症处理等,下同）。对照组：感染期间予常规治疗外,于每次感染时如体温〉37.3℃者即予苯巴比妥片口服,3~5 mg/（kg·次）,3次/d,维持用药至体温恢复正常,共预防给药一年。空白对照组：仅于感染期间予常规治疗。结果 （1）观察组于第一观察年呼吸道感染、发热和惊厥例次少于空白对照组,并且第二观察年其疗效仍持续稳定提高。（2）对照组于第一观察年内其控制惊厥发作例次少于空白对照组（P〈0.01）,与观察组相当,但第二年停止预防性服药后,患儿惊厥例次有所反弹。（3）三组观察病例随着时间推移,呼吸道感染次数均渐次减少,组内前后对比差异都具统计学意义（P〈0.01）,组间比较以观察组疗效最佳,对照组与空白对照组相当（P〉0.05）。结论防惊散能有效减少患儿呼吸道感染、发热、惊厥发作例次,推测防惊散除具有直接预防惊厥之外,还可以通过调节机体状态,提高免疫机能,从而减少呼吸道感染、减少发热从而达到减少惊厥发作之目的。

Objective To observe the effect of fangjingsan in children with febrile seizures control. Methods 120 cases of febrile seizures in children were randomly divided into three groups of 40 each. Treatment group： anti-fright one day,sooner or later boiled water,once every 30 days after the withdrawal. During the infection only to conventional treatment（antibiotics,antipyretic,symptomatic treatment,the same below）. Control group： during infection to conventional treatment,such as infection at the time of each temperature〉37.3℃ by the verdict,phenobarbital tablets for oral,3 ~ 5 mg/（kg·times）,3 times/day,medication to maintain the body temperature returned to normal,total prophylaxis year. Control group： only received conventional treatment during infection. Results（1）observation group and the first observation of respiratory infections,fever and convulsions cases significantly less than the control group,and the second observation of its efficacy remains steady increase.（2）control group was observed in the first year of its control seizures cases significantly less than the control group（P〈0.01）,comparable to the observation group,but stopped after the second year of preventive medication,convulsions cases rebound.（3）three cases observed over time,the number of respiratory infections are gradually reduced in the group before and after comparison with the differences are significant（P〈0.01）,between the two groups in order to best observation group,the control group and the control group is quite（P〈0.05）. Conclusion Anti-fright can effectively reduce respiratory infections in children,fever,seizure cases,in addition to having antifright speculate directly prevent seizures,but also can adjust the body＇s condition,improve immune function,thereby reducing respiratory infection,reduce the heat so as to achieve the objective of reducing seizures.