奥扎格雷联合法舒地尔治疗急性脑梗死效果观察

The Effects of Ozagrel Combined with Fasudil in Acute Cerebral Infarction

目的探讨奥扎格雷联合法舒地尔治疗急性脑梗死的临床效果。方法选取96例急性脑梗死住院患者随机分为观察组和对照组，分别给予奥扎格雷联合法舒地尔治疗和仅采用奥扎格雷治疗，比较两组患者临床疗效、治疗前后NIHSS、ADL评分及不良反应发生情况。结果观察组临床有效率为97．92％，高于对照组的83．33％（P〈0．05）；治疗后两组患者NIHSS显著降低，ADL评分显著提高，且治疗后观察组患者ADL评分高于对照组，NIHSS评分低于对照组，差异均有统计学意义（P〈0．05）；两组患者的不良反应发生率差异无统计学意义（P〉0．05）。结论奥扎格雷联合法舒地尔治疗急性脑梗死可提高临床疗效，改善患者临床症状，提高患者日常生活能力，且安全性较高。

Objective To explore effects of ozagrel combined with fasudil in acute cerebral infarction. Methods 96 patients with acute cerebral infarction were randomly divided into experimental group and control group. Ozagrel combined with fasudil treatment and only fasudil treatment were used in two groups. Clinical efficacy, NIHSS, ADL score and adverse reactions before and after treatment were compared. Results Effective rate was 97.92% in experimental group,which was higher than 83.33 % in the control group（P 〈 0.05 ）. NIHSS decreased and ADL score increased after treatment in the two groups. ADL score was significantly higher in experimental group than that in control group after treatment and NIHSS was significantly lower than that in the control group（P 〈 0.05 ）. There were no significant differences in adverse reactions between the two groups （P 〉 0. 05 ）. Conclusion Ozagrel combined with fasudil in the treatment of acute cerebral infarction can improve clinical efficacy, clinical symptoms and patients＇activities of daily living with higher safety.