摘要
脑胶质瘤干细胞存在于微环境中,微环境中包含有多种的细胞信号调控分子,胶质瘤的生物学行为正是由细胞外微环境作用于细胞内信号所决定的。脑胶质瘤干细胞信号通路的研究已成为脑胶质瘤研究的热点。本文将重点综述脑胶质瘤干细胞中几条重要的与神经干细胞相关的信号通路,为更全面的认识脑胶质瘤细胞信号、以及开拓新的脑胶质瘤治疗方法提供基础证据。
Glioma stem cells exist in the micro environment, which contains a variety of cell signal transduction molecules, and biological behavior of glioma is regulated by extracellular microenvironment on the intracellular signal. Glioma stem cell signaling pathways study has become the hot topics in the study of glioma. This review focuses on several important in glioma stem cells related to neural stem cell signaling pathways, for a more comprehensive understanding of glioma cell signal, and provide basic evidence to explore new glioma treatment.
出处
《中华神经创伤外科电子杂志》
2015年第5期41-45,共5页
Chinese Journal Of Neurotraumatic Surgery：Electronic Edition
基金
广东省药学会基金(2011X19)
国家自然科学基金(30801184)
广东省科技计划重点专项(2011A030400007)
关键词
脑肿瘤
干细胞
信号通路
Brain tumor
Stem cells
Signaling pathways
