乙型肝炎肝硬化的分期及治疗进展

Advances in staging and treatment of hepatitis B cirrhosis

肝硬化是慢性乙型肝炎疾病进展的重要阶段,明确肝硬化严重程度对评估预后至关重要,目前以肝硬化并发症为基础的临床分期应用广泛,而病理分期仍有待细化。治疗方面,2015年各肝病学会相继更新了慢性乙型肝炎诊疗指南,乙型肝炎肝硬化的抗病毒治疗较前更加积极。预后方面,有效的抗病毒治疗实现了早期肝硬化的逆转,降低了肝病相关终点事件的发生,但逆转的机制仍有待进一步探讨。

Liver cirrhosis is an important stage of the progression of chronic hepatitis B, and it is of great significance to clarify the severity of liver cirrhosis in evaluating prognosis. At present, the clinical staging based on tile complications of liver cirrhosis is widely used, but pathological staging still needs to be refined. In the aspect of treatment, liver disease associations updated the guidelines for the diagnosis and treatment of chronic hepatitis B in 2015, and the antiviral therapy for hepatitis B cirrhosis has become more active. As for the prognosis, effective antiviral treatment realizes the reversion of early cirrhosis and reduces the incidence of liver - related complications, but the mecha- nism of reversion awaits further investigation.