间充质干细胞在肝硬化基础研究和临床应用中的进展

Advances in basic research on mesenchymal stem cells and its clinical application in liver cirrhosis

成体间充质干细胞具有可塑性高、低免疫原性等特点,拥有广泛的临床应用前景。综述了骨髓和脐血间充质干细胞治疗肝脏疾病中的基础研究和临床应用进展,为骨髓和脐血间充质干细胞治疗肝硬化的临床应用奠定理论基础和实践支持,为终末期肝病的治疗提供了更多的技术手段。但是临床应用的安全性和有效性问题仍然需要进一步探讨。

Adult mesenchymal stem cells （MSCs） have the features of high plasticity and low immunogenicity, and hold promise for wide clinical application. This article reviews the basic research on MSCs in bone marrow and umbilical cord blood and their clinical application in liver diseases to lay a theoretical foundation and provide support for their clinieal application in liver cirrhosis, and to provide more technieal measures for the treatment of end - stage liver disease. However, the safety and efficacy in clinical application still need further studies.