滤泡辅助性T淋巴细胞及其在肝脏疾病发生发展中的作用

Role of follicular helper T cells in development and progression of liver diseases

滤泡辅助性T淋巴细胞(TFH)是近年来发现的辅助B淋巴细胞产生抗体的新型CD4+T淋巴细胞亚群,与肝脏疾病的发生发展密切相关。综述了TFH的发现、分化及相关的功能分子,通过产生白细胞介素21辅助B淋巴细胞产生抗体的机制,及在慢性乙型肝炎、慢性丙型肝炎、自身免疫性肝炎、原发性胆汁性肝硬化、肝衰竭、肝移植等肝脏疾病发生发展中的作用。指出TFH可能成为治疗肝脏疾病的新型靶细胞。

Follicular helper T cell （TFH） is a new CD4 ＋ T lymphocyte subset which helps B lymphocytes to produce antibodies and is closely related to the development and progression of liver diseases. This article reviews the detection and differentiation of TFH and related functional molecules, the mechanism of action of TFH in helping B lymphocytes to produce antibodies through producing interleukin -21, as well as the role of TFH in liver diseases such as chronic hepatitis B, chronic hepatitis C, autoimmune hepatitis, primary biliary cirrhosis, he- patic failure, and liver transplantation, and points out that TFH may become the new target cell in the treatment of liver diseases.