胸腺五肽结合抗生素对老年慢性阻塞性肺疾病急性加重期的疗效

Curative effect of thymopentin combined with antibiotics in the treatment of elderly patients with chronic obstructive pulmonary disease at acute exacerbation stage

目的：探析胸腺五肽结合抗生素对老年慢阻肺急性加重期的疗效。方法本研究对象为我院及广州市民政局精神病院2012年12月～2015年12月收治的120例老年慢阻肺急性加重期患者，并随机分成对照组（60例）和观察组（60例）。两组患者均予以持续吸氧、止咳化痰、解痉平喘等常规基础治疗，对照组采取抗生素治疗，观察组采取胸腺五肽结合抗生素治疗。结果观察组老年慢阻肺急性加重期患者经治疗后，其PEF、FEV1、FEF25%、FEF50%、FEF75%等各项肺功能指标和总有效率均显著高于对照组（P＜0.05）；观察组和对照组患者治疗后的不良反应发生率差异无统计学意义（P＞0.05）。结论胸腺五肽结合抗生素对老年慢阻肺急性加重期的疗效显著，可有效改善患者的肺功能，且具有一定的安全性。

Objective To explore the curative effect of thymopentin combined with antibiotics in the treatment of elderly patients with chronic obstructive pulmonary disease at acute exacerbation stage.Methods 120 elderly patients with chronic obstructive pulmonary disease at acute exacerbation stage who were in our center and Mental hospital of Guangzhou Civil Administration Bureau from December 2012 to December 2015 were randomly divided into control group and observation group, 60 cases in each group. Based on the routine therapy of continuous oxygen inhalation, relieving cough, reducing sputum, spasmolysis, and relieving asthma, the control group was treated with antibiotic, and the observation group was treated with thymopentin and antibiotics. Results After treatment, in the observation group, the lung functional indexes of PEF, FEV1, FEF25%,FEF50%,FEF75% and total effective rate were obviously higher than those of the control group （P〈0.05）,the adverse reaction rates of the two groups were not statistically different （P〉0.05）. Conclusion The therapy of thymopentin combined with antibiotics is effective in the treatment of elderly patients with chronic obstructive pulmonary disease at acute exacerbation stage, which can obviously improve the lung functions of patients, and is safe to some extent.