清晨尿微量白蛋白尿肌酐比测定在糖尿病肾病患者肾小球损害诊断中的价值分析

The value of urine micro albumin/urine creatinine on renal injury in patients with diabetic nephropathy

目的探讨清晨尿微量白蛋白尿肌酐比(Um Alb/Ucr)测定对糖尿病肾病(DN)早期肾小球损害的诊断价值。方法选取100例DN患者为观察组,100例健康人员为对照组,收集两组清晨静脉血、尿标本,分析两组尿微量白蛋白尿肌酐比(Um Alb/Ucr),血清胱抑素C(Cys C),血肌酐(Scr)及血尿素氮(BUN)四种方法的检测结果及诊断效能。结果观察组Um Alb/Ucr及Cys C均显著高于对照组,而在Scr、BUN水平上未见差异;同时研究中Um Alb/Ucr与Cys C无论是在灵敏度,特异度还是准确度均未见显著差异,且在三项效能上均明显高于Scr、BUN两种检查(P<0.05);而Scr与BUN比较,灵敏度、特异度及准确度均无明显差异。结论清晨Um Alb测定配合UCr进行校正,能够及时发现DN患者早期肾小球损害,操作简便,特异度、灵敏度高,值得临床推广应用。

Objective To study the diagnostic value of urine micro albumin/ urine creatinine （UmAlb/Ucr） on renal injury in patients with Diabetic nephropathy.Methods 100 DN patients were chosen as observation group, and 100 healthy people were selected as control group. The venous blood and urine of the 2 groups were collected in morning. The results of the determination was analyzed, such as UmAlb/Ucr, cystatin C （CysC）, serum creatinine（Scr） and usea nitrogen （BUN）. The diagnostic efficiency was diagnosed.Results The level of UmAlb/Ucr and CysC of observation group were much higher than those of the control group. There was no difference in the level of BUN and Scr between the two groups. UmAlb/Ucr and CysC showed no significant difference in sensitivity, specificity and accuracy. The three efficacy was significantly higher than Scr and BUN （P〈0.05）. There was no significant difference in sensitivity, specificity and accuracy between Scr and BUN.ConclusionUmAlb determination with UCr can be timely detection of early glomerular damage in patients with Diabetic nephropathy, owning a significant effect, worthy of clinical. It is easy to operate, specificity, high sensitivity. It is worthy of clinical application.