血清胱抑素C和同型半胱氨酸在原发性高血压患者早期肾功能损害中的临床价值

The clinical value of serum cystatin C and homocysteine in renal function damage of patients with primary hypertension

目的探讨血清胱抑素C和同型半胱氨酸在原发性高血压患者早期肾功能损害中的变化及临床价值。方法收集原发性高血压患者86例,按肌酐清除率值将86例患者分为观察组(早期肾功能损伤组)和对照组(肾功能正常组)。检测每组血清Hcy、Cys-C、24h尿微量白蛋白(24hm ALb)、血肌酐(SCr)和尿素氮(BUN),比较两组之间的差异,并对Cys-C和Hcy进行相关性分析。结果观察组患者与对照组比较,血清Cys-C、Hcy、24hm ALb差异具有统计学意义(P<0.05),SCr和BUN差异无统计学意义(P>0.05)。Pearson相关分析显示血清Cys-C和Hcy为正相关。结论血清Cys-C和Hcy在原发性高血压患者早期肾功能损害检测中具有重要的临床价值。

Objective To investigate the change and clinical value of serum cystatin C and the same type of homocysteine in renal function damage of patients with primary hypertension. Methods86 patients with primary hypertension were collected and were divided into the observation group （early renal function injury group） and the control group （normal renal function group） according to the creatinine clearance rate （CCr） values.The serum Hcy,Cys-C,24h urine micro albumin （24hmALb）,serum creatinine （SCr） and urea nitrogen （BUN） of the two groups were detected and compared.The Cys-C and Hcyhas were analyzed for correlation.Results The differences of serum Cys-C,Hcy and 24hmALb betweem two groups were statistically significant,and there was no significant difference in SCr and BUN between two groups.Pearson correlation analysis showed that the serum Cys-C and Hcy were positively correlated.The observation group of patients compared with control group,serum Cys-C,Hcy,24 hmalb differences statistically significant（P〈0.05）,there was no statistically significant difference of SCr and BUN（P〉0.05）.Pearson correlation analysis showed that the serum Cys C and Hcy was positive correlation.ConclusionSerum Cys-C and Hcy have important clinical value in the detection of early renal function damage of patients with essential hypertension.