期刊文献+

白介素-7与肿瘤关系的研究进展 被引量:1

Reseach progress on the relationship between Interleukin-7 and tumor
下载PDF
导出
摘要 白介素-7(IL-7)参与胸腺细胞分化、成熟,是T淋巴细胞发育、增殖、动态平稳及发挥正常功能所必需的细胞因子,对B淋巴细胞、树突细胞、巨噬细胞的发育分化也有一定作用。其具有强有力的免疫调节作用,可增强肿瘤疫苗及过继免疫治疗疗效。鉴于IL-7特殊的生物学特性,其在骨髓移植、严重联合免疫缺陷、感染以及肿瘤等治疗中的应用现已成为研究的热点。本文从IL-7的生物学特性、在肿瘤治疗方面的研究进展进行了总结。
作者 陈样 勾红峰
出处 《实用医院临床杂志》 2016年第4期212-214,共3页 Practical Journal of Clinical Medicine
  • 相关文献

参考文献24

  • 1Whitlock CA, Robertson D, Witte ON. Murine B cell lymphopoiesis in long term culture[J]. J Immunol Methods,1984,67(2) :353-369.
  • 2Milne CD, Paige CJ. IL-7 : a key regulator of B lymphopoiesis [J]. Se- min Immuno1,2006,18 ( 1 ) :20-30.
  • 3Fry TJ, Mackall CL. Interleukin-7 : from bench to clinic [ J ]. Blood, 2002,99( 11 ) :3892-3904.
  • 4Patra AK, Avots A,Zahedi RP,et al. An ahemative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development [ J]. Nat Immuno1,2013,14 (2) : 127-135.
  • 5Surh CD,Sprent J. Homeostasis of naive and memory T cells[ J ]. Im- munity,2008,29 ( 6 ) : 848 -862.
  • 6Crawley AM,Vranjkovic A, Faller E,et al. Jak/STAT and PI3K sig- naling pathways have both common and distinct roles in IL-7-media- ted activities in human CD8+ T cells [ J ]. J Leukoc Biol, 2014,95 (1) :117-127.
  • 7Lawson BR, Gonzalez-Quintial R, Eleflheriadis T, et al. Interleukin-7 is required for CD4 (+) T cell activation and autoimmune neuroin- flammation [ J ]. Clin Immuno1,2015,161 ( 2 ) :260-269.
  • 8Rosenberg SA, Sportes C, Ahmadzadeh M, et al. IL-7 administration to humans leads to expansion of CD8+ and CD4+ cells but a relative decrease of CD4+ T-regulatory cells [J].J Immunother, 2006,29 (3) :313-319.
  • 9Ribeiro VS, Hasan M, Wilson A, et at. Cutting edge : Thymic NK cells develop independently from T cell precursors [ J ]. J Immunol,2010, 185 (9) :4993-4997.
  • 10Pellegrini M, Calzaseia T, Elford AR, et al. Adjuvant IL-7 antagoni- zes multiple cellular and molecular inhibitory networks to enhance immunotherapies [J]. Nat Med,2009,15 (5) :528-536.

同被引文献5

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部