不同类型宫颈病变患者高危型HPV感染情况分析

High-risk HPV infection analysis in patients with different types of cervical lesions

目的分析不同类型宫颈病变患者高危型人乳头瘤病毒(HPV)感染情况。方法于2012年5月至2015年5月随机选择宫颈病变患者1 007例,对高危型HPV检测结果进行统计学分析。结果 1 007例宫颈病变患者中,检出高危型HPV阳性429例,感染率为42.6%。宫颈上皮内瘤变(CIN)Ⅱ、CINⅢ患者高危型HPV感染率高于CINⅠ、子宫颈炎患者(P<0.05)。不同年龄段宫颈病变患者高危型HPV感染率比较差异无统计学意义(P>0.05)。随着宫颈病变程度的加重,HPV病毒载量平均值逐渐升高,但不同类型宫颈病变患者中HPV感染者病毒载量平均值比较差异无统计学意义(P>0.05)。结论宫颈病变的发生、发展和高危型HPV感染相关,高危型HPV感染率随着病变程度的加重而升高。在筛查宫颈癌、判断癌前病变及患者治疗随访过程中,均应重视高危型HPV检测。

Objective To analyze the high‐risk human papilloma virus（HPV） infection status in patients with different types of cervical lesions .Methods Clinical data of 1 007 patients with cervical lesions ,collected from May 2012 to May 2015 ,were statisti‐cally analyzed .Results Among the 1 007 patients with cervical lesions ,429 cases were HPV‐positive ,and the high‐risk HPV infec‐tion rate was 42 .6% .The high‐risk HPV infection rate of patients with cervical intra‐epithelial neoplasia（CIN）Ⅱ and CINⅢ were significantly higher than patients with CIN Ⅰ and cervicitis（P〈0 .05） .The differences of high‐risk HPV infection rates between patients of different ages were not significant （P〉0 .05） .With the increasing of degree of CIN ,mean value of HPV viral load gradu‐ally improved ,but of patients with different types of cervical lesions and high‐risk HPV infection ,the differences of viral load were not significant（P〉0 .05） .Conclusion The development of cervical lesions could be related with high‐risk HPV infection .High‐risk HPV infection rate could be increased with the improvement of disease severity .Detection of high‐risk HPV should be utilized in the screening of cervical cancer and precancerous lesions ,and post‐treatment follow‐up process .