利用CRISPR/Cas9介导基因编辑人类三核受精卵伦理问题探讨

Ethical Inquiries about CRISPR/Cas9-mediated Gene Editing in Human Tripronuclear Zygotes

以广州中山大学黄军就博士2015年发表在Protein&Cell杂志上一篇引起广泛关注和伦理争议的论文为背景,分析了使用CRISPR/Cas9介导基因编辑人类三核受精卵存在的伦理问题,探讨了相关研究最终可能导致优生和定制胎儿的后果,评价了此项研究引发的国际国内伦理争论,分析了"先干起来,干了再说"的非理性观点。认为现阶段应对相关研究加以规范,在技术尚不成熟的情况下,不能随意开展人类生殖细胞和人类胚胎基因编辑基础研究,更不能推广到临床研究。

With extraordinary deliberation, the online journal Protein ＆ Cell published Huang Junjiu and his colleagues~ research of ＂Crispr/Cas9-mediated gene editing in human tripronuclear zygotes＂, which has raised ethical controversies to the field of gene editing technology especially in human germ cell and embryos. This paper discussed the ethical problems caused by Dr. Huang＇s research in CRISPR-based gene editing technology in tripronuclear zygotes and human embryos, analyzed the should be consequences of making infant or designer baby lead by this gene editing technology, commented on the ethical debates in domestic and abroad perspectives, criticized the irrational view of ＂do first, talk later＂. It addressed that we should regulate the related researches. In the current immature phase of technology development, we should not conduct the basic research of gene editing in human germ cells and embryos at will, especially the clinical research.