炎症性肠病患者低磷血症发生率及相关因素分析

Prevalence of hypophosphatemia and its related factors in patients with inflammatory bowel disease

目的:研究炎症性肠病(IBD)患者低磷血症发生率及相关危险因素。方法 :纳入2013年1月至2015年12月我院接受肠外营养治疗前的住院IBD患者,包括溃疡性结肠炎(UC)和克罗恩病(CD)患者。收集患者的一般资料、疾病相关指标和入院时血生化检查。分析低磷血症的发生情况。Pearson相关分析分析2组患者发生低磷血症的相关危险因素。结果:共纳入IBD患者146例,其中UC 68例,CD 78例。低磷血症总发生率为26.0%(38/146),其中轻度19例(13.0%)、中度17例(11.6%)、重度2例(1.4%);UC患者与CD患者低磷血症发生率无明显差异。Pearson相关分析显示:UC患者体质量指数(BMI)、清蛋白、钙、镁与血磷呈正相关(r分别为0.370、0.314、0.424、0.986,P分别为0.002、0.009、<0.001、<0.001);CD患者中,血磷除与清蛋白、钙和镁呈明显正相关外(r分别为0.327、0.361、0.985,P分别为0.004、0.001、<0.001),还与年龄呈负相关(r=-0.237,P=0.037)。Logistic回归分析结果显示老龄(≥65岁)和低钙是低磷血症发生的危险因素。结论:IBD患者低磷血症发生率为26.0%。老龄和低钙是低磷血症发生的危险因素。

Objective To evaluate the prevalence of hypophosphatemia and its related factors in patients with inflammatory bowel diseases（IBD）.Methods A retrospective study was performed in hospitalized IBD patients.Descriptive data,disease related data and biochemical data were obtained from the medical records.The prevalence of hypophosphatemia was evaluated,and the risk factors for hypophosphatemia were analyzed by Pearson correlation test.Results One hundred and forty six IBD patients were recruited for the study（UC/CD =68/78）.The prevalence of hypophosphatemia was 26.0%（38/146） in the study population.Among them,19（13.0%） patients were mild,17（11.6%）were moderate,and 2（1.4%） were severe.There was no obvious difference in the prevalence of hypophosphatemia between UC and CD groups.Pearson correlation analysis showed that serum phosphorus was positively correlated with body mass index（BMI）,albumin,calcium and magnesium（r=0.370,0.314,0.424,0.986,respectively,all P〈0.01）in UC group;and was positively correlated with albumin,calcium and magnesium（r=0.327,0.361,0.985,respectively,all P〈0.01） and negatively correlated with age（r=-0.237,P=0.037） in CD group.Aging（≥65 years old） and hypocalcemia were assessed to be the risk factors for hypophosphatemia by Logistic regression analysis.Conclusions The prevalence of hypophosphatemia was26.0% in this study.Aging and hypocalcemia were the risk factors for hypophosphatemia.