肝动脉栓塞联合T细胞克隆技术治疗结肠癌肝转移临床研究

Clinical study of hepatic artery embolization combined with T cell cloning technology in the treatment of liver metastasis from colon cancer

目的探讨肝动脉栓塞(TACE)联合T细胞克隆技术治疗结肠癌肝转移的临床疗效。方法选择2010年1月~2014年12月结肠癌肝转移患者64例的临床资料进行回顾性分析,33例患者给予肝动脉栓塞治疗为对照组,31例患者在此基础上给予T细胞克隆技术治疗为研究组。比较两组的临床疗效及治疗后外周血T细胞亚群。结果研究组总有效率显著高于对照组,差异有统计学意义(P<0.05)。研究组治疗后总T细胞亚群、CD4^+T细胞亚群、CD8^+T细胞亚群显著高于对照组,差异有高度统计学意义(P<0.01)。结论肝动脉栓塞联合T细胞克隆技术治疗结肠癌肝转移能够改善患者的预后。

Objective To discuss clinical efficacy of hepatic artery embolization combined with T cell cloning technology in the treatment of liver metastasis from colon cancer. Methods Clinical data of 64 cases with liver metastasis from colon cancer from Jan 2010 to Dec 2014 were respectively analyzed. 33 cases of control group were treated with hepatic arterial embolization, and 31 cases of study group were treated with hepatic artery embolization combined with T cell cloning technology. Clinical efficacy and peripheral blood T cell subsets after treatment of two groups were compared. Results Total effective rate of study group was higher than control group（P〈0.05）. After treatment, the total T cell sub- sets CD4＋T cell subsets and CDS＋T cell subsets in study group were higher than control group（P〈0.01）. Conclusion Hepatic artery embolization combined with T cell cloning technology in the treatment of liver metastasis from colon cancer can improve the prognosis.