贝前列素钠片及缬沙坦联合治疗老年下肢动脉狭窄的临床观察

Efficacy of combination of Beraprost Sodium Tablets and Valsartan in the treatment of elderly patients with hypertension and diabetes with arteriosclerosis obliterans(ASO)

目的 探讨联合口服贝前列素钠片及缬沙坦治疗高血压合并糖尿病下肢动脉硬化闭塞症的疗效及安全性,探索出能够长期治疗下肢动脉狭窄的临床方法。方法 选取2012年3月~2014年8月在我院干诊及内分泌科住院的、确诊老年高血压合并糖尿病下肢动脉狭窄患者51例,经过联合口服贝前列素钠片及缬沙坦治疗1年,观察治疗前后患者的血压、最远走行距离、下肢动脉血管内径、血流峰时速度。结果 治疗后1年较治疗前患者血压达标（P〈0.01）,最远走行距离显著延长,治疗前为（57.9±9.6）m,治疗后为（683.4±20.7）m,差异有统计学意（P〈0.05）。治疗后较治疗前下肢主要动脉血管内径增宽及对应血流速度增快,差异均有统计学意义（P〈0.05）。结论对于老年高血压合并糖尿病下肢动脉狭窄患者,联合口服贝前列素钠片及缬沙坦治疗下肢动脉硬化闭塞症是一种临床上安全有效的方法。

Objective To investigate the efficacy and safety of combined therapy of Beraprost Sodium Tablets and Val- sartan in the treatment of arteriosclerosis obliterans （ASO） in patients with hypertension and diabetes,and find the ef- fective method to ASO. Methods 51 patients with hypertension and diabetes mellitus in March 2012-August 2014 in our hospital,were diagnosed as ASO. After the combined administration of Beraprost Sodium Tablets and Valsartan for 1 year, observing the blood pressure,the walk distance without causing pain,lower extremity arterial blood vessel di- ameter,blood flow peak velocity before and after treatment. Results There was significant difference of blood pressure before and 1 year after treatment. The walk distance without eausing pain after the treatment was significantly longer than before[（57.9±9.6）m vs （683.4±20.7）m],and there was statistieal significant difference（P〈0.05）. Before and after treatment,there were statistically signifieant difference of the main artery diameter and blood flow velocity （P〈0.05）. Conclusion For elderly ASO patients with hypertension and diabetes,the combined therapy with Beraprost Sodium Tablets and Valsartan is a safe and effeetive method in elinieal praetice.