脑血管反应性与尤瑞克林治疗急性脑梗死预后分析

Analysis of the prognosis of cerebrovascular reactivity and urinary kallidinogenase in the treatment of acute cerebral infarction

目的观察脑血管反应性同尤瑞克林治疗急性脑梗死预后的相关性。方法选取急性脑梗死患者90例作为研究对象进行随机单盲对照研究试验,采用随机、单盲、对照方式分为研究组和参照组。给予参照组常规治疗方式,给予研究组在此基础上采用尤瑞克林进行治疗。在患者治疗前以及治疗第15天,对脑卒中量表(NIHSS)评分、改良残疾程度量表(m RS)评分进行记录,并且对于HBI同NIHSS的评分、m RS评分的下降程度进行相关性分析。结果在经过不同方式的治疗以后,治疗第15天研究和参照组患者的NIHSS评分以及m RS评分明显下降(P<0.05);同时在治疗第15天,两组患者的NIHSS评分与m RS评分相比较,差异有统计学意义(P<0.05)。此外,经过分析显示,在治疗的第15天,研究组患者获得的HBI和NIHSS评分的下降幅度同m RS评分的下降幅度之间呈正相关(P<0.01);参照组患者的HBI和NIHSS评分的下降程度呈正相关(P<0.01),同时其HBI同m RS评分的下降程度之间不具有线性相关性联系(P>0.05)。结论脑血管反应性与尤瑞克林治疗急性脑梗死患者短期预后,具有正相关性。

Objective To observe and explore the relevance between the prognosis and cerebrovascular reactivity and urinary kallidinogenase in the treatment of acute cerebral infarction. Methods A randomized single-blinded control study was conducted： 90 patients with acute cerebral infarction were selected as the study subjects, and they were as- signed to the research group and the control group with the randomized, single-blinded and controlled method. Regular treatment methods were given in the control group, and urinary kallidinogenase was given in the research group on the basis of the control group. NIHSS scores, and mRS scores were recorded before the treatment and 15 days after the treatment, and the relevance analysis of decreasing degree of HBI and NIHSS scores and mRS scores was carried out. Results After different approaches of treatment, NIHSS scores and mRS scores on the fifteenth day of the treatment in the research and control group were significantly reduced （P〈O.05）; on the fifteenth day of the treatment, NIHSS scores and mRS scores were compared between both groups（P〈0.05）. In addition, the analysis showed that on the fifteenth day of the treatment, the decreasing degree of HBI and NIHSS scores acquired by the patients in the research group was positively relevant to the decreasing degree of mRS scores （P〈0.001）; the decreasing degree of HBI and NIHSS scores acquired by the patients in the control group was positively relevant （P〈0.001）. Meanwhile, HBI was not linearly corre- lated to the decreasing degree of mRS scores （P〉0.05）. Conclusion Cerebrovascular reactivity and urinary kallidino- genase in the treatment of acute cerebral infarction is positively correlated to patients＂ short-term prognosis.