胰腺内分泌肿瘤1例临床病理分析

Clinical pathological analysis of pancreatic endocrine tumor

目的探讨胰腺内分泌肿瘤的临床病理学特征。方法结合1例胰腺内分泌来源肿瘤伴左眼眶及肝脏转移的临床和病理资料,分析该病的临床、病理、诊断、鉴别诊断、治疗方法及预后特征。结果此患者以左眼眶占位为主诉入院,术后经病理证实为此病转移至眼眶,肿瘤细胞异型性不明显,需要免疫组化检查与胰腺内分泌成分增生等疾病鉴别。予以手术治疗及化疗。随访患者于1年后病故。结论胰腺内分泌来源肿瘤非常罕见,其症状复杂多样,病程缓慢,临床误诊和漏诊常见,容易导致患者长期误诊误治,甚至出现严重不可逆的损害。主要依靠术后病理组织学及免疫组化检查,手术切除是其主要治疗手段,预后较其他胰腺导管腺癌好。

Objective To investigate the clinical pathological characteristics of pancreatic endocrine tumor. Methods The clinical and pathological data of 1 case of pancreatic endocrine tumor combined with metastasis of left orbit and liver was referred and the clinical, pathological, diagnosis, differential diagnosis, treatment and prognostic characteris- tics were analyzed. Results The complaint of the patient was occupation of left orbit and metastasis of orbit was proved by the postoperative pathology, the atypia of the tumor eells were not obvious and the immunohistoehemieal examina- tion and differential diagnosis of hyperplasia of panereatie endocrine was needed. Operation and chemotherapy was giv- en to the patient. The patient was dead after one-year follow-up. Conclusion The pancreatic endocrine tumor is rare with complicated symptoms and slow progress. It is common to misdiagnose and missed diagnose, whieh will lead to long-term misdiagnose and missed diagnose and even severe irreversible damages. Postoperative pathological examina- tion and mmunohistoehemical examination is relied on with the predominate treatment of surgical reseetion. The prog- nosis of the disease is better than other pancreatic duetal adenoearcinoma.