多烯磷脂酰胆碱治疗酒精性肝病伴脂肪肝的疗效评价

Evaluation of fatty liver in alcoholic liver disease with multi - phosphatidylcholine

背景：多烯磷脂酰胆碱可促进肝细胞再生，缓解脂肪肝病变或坏死。目的：探讨多烯磷脂酰胆碱治疗酒精性肝病和脂肪肝的临床疗效。方法：选择101例酒精性脂肪肝患者作为研究对象，随机分成2组。对照组接受异甘草酸镁治疗，观察组在对照组治疗基础上再接受多烯磷脂酰胆碱治疗。对比两组临床疗效及不良反应情况。结果与结论：观察组治疗第2，3，4周临床治疗总有效率均明显优于对照组（P均〈0．05）；观察组与对照组不良反应比较差异无显著性意义（P〉0．05）。结果表明，在异甘草酸镁基础上使用多烯磷脂酰胆碱治疗酒精性肝病和脂肪肝，临床疗效更显著且不增加用药不良反应，是一种较为有效的，临床治疗方法。

Objective： To investigate the clinical effect of the treatment of alcoholic liver disease and fatty liver by multi- phosphatidylcholine. Method 101 cases of alcoholic fatty liver were randomly divided into 2 groups, The control group received the treatment of magnesium isoglycyrrhizinate, On this basis, the observation group received the treatment of phosphatidylcholine, The clinical effect and adverse reaction of the two groups were observed and compared. Result： The total effective rate of the observation group was significantly better than that of the control group at 2, 3 and 4 weeks, which was significantly better than that of the control group （mean P 〈0.05）.There was no significant difference in adverse reactions between the observation group and the control group （P 〉0.05）. Conclusion The use of magnesium isoglycyrrhizinate in the treatment of alcoholic liver disease and fatty liver in diammonium glycyrrhizinate basis compared with Diammonium Glycyrrhizinate more significant and does not increase the adverse drug reaction, is a more effective method in clinical therapy.