IL-1α和IL-6在脑膜瘤和脊膜瘤中的表达及意义

Expression and significance of IL-1α and IL-6 in the spinal and intracranial meningiomas

目的探讨脑膜瘤(IM)和脊膜瘤(SM)中IL-1α和IL-6的表达及其临床意义。方法采用免疫组化方法检测IM(IM组,118例)和SM(SM组,44例)中的IL-1α和IL-6表达水平,分析其组间及其病理分型之间的表达差异。结果 IM和SM病理分型的各亚型之间,IL-1α和IL-6的表达均有统计学差异(P<0.05)。非良性IM组的IL-1α阳性率为78.9%,高于良性IM组的33.3%(P<0.05);非良性IM组的IL-6阳性率为31.6%,与良性IM组的17.2%相仿(P>0.05)。结论IM与SM组织及其病理分型的IL-1α和IL-6表达水平有显著差异,可为临床诊断提供一定参考。

Objective To investigate the expressions and significance of IL-1α and IL-6 in the spinal meningioma（SM） and intracranial meningioma（IM）. Methods The expressions of IL-1α and IL-6 were detected with immunohistochemistry in the specimens of IM（group IM, 118 cases） and SM （group SM,44 cases）. The differences of IL-1α and IL-6 expressions between two groups and among different pathological subtypes of IM and SM were analyzed. Results The expressions of IL-1α and IL-6 were different among different pathological subtypes of IM and SM specimens （P〈0. 05）. The positive expression rate of IL-1α was higher in the specimens of unbenign IM than that in those of benign（78. 9% vs. 33.3%） （P〈0. 05）, which of IL-6 was similar（31.6% vs. 17.2%） （P〈0. 05）. Conclusion The significant differences in the expressions of IL-1α and IL-6 exist between IM and SM and among different pathological subtypes of them, which might provide a certain reference in the diagnosis of IM and SM.