钙化上皮瘤195例临床及病理分析

Clinical and pathological analysis on 195 cases of calcifying epithelioma

目的分析钙化上皮瘤临床及病理学特点。方法回顾性分析195例钙化上皮瘤患者的临床、病理资料。结果钙化上皮瘤患者以女性居多,男女比为1∶1.2;患者平均年龄21.6岁,≤20岁占63.1%;发生部位以头面部居多,占56.8%,其次为颈项部占19.6%,乳腺、阴囊也可发生,偶有多发患者,不排除再发患者;临床误诊率高;组织病理主要表现为影细胞及嗜碱性细胞团片状排列;手术完整切除后原发部位未见复发。结论钙化上皮瘤好发于青少年女性头面颈部,手术完整切除是首选的治疗方法,预后良好。

Objective To analyze the clinical and pathological characteristics of calcifying epithelioma. Methods The clinical and pathological data of 195 patients with calcifying epithelioma were retrospectively analyzed. Results Calcifying epithelioma was more common in the female,and the ratio of the male to the female was 1 ∶ 1. 2. The average age of the patients was 21. 6 years,and the patients aged 20 years or younger accounted for 63. 1%. The most common occurrence sites were head and face（ 56. 8%）,and the secondary was neck（ 19. 6%）. The calcifying epithelioma also occurred in breast and scrotum. Multiple lesions were occasionally found,and the patients with recurrent lesions can not be excluded. The clinical misdiagnosing rate was high. The shadow cells and the alkaline cells arranging into a mass were the main histopathological features. No recurrence was found in the primary site after a complete resection. Conclusion The head,face and neck are the common sites of calcifying epithelium in the young female. Complete surgical resection is the first choice of treatment and can obtains a good prognosis.