糖皮质激素对狼疮性肾炎患者活动性作用与肾内B淋巴细胞刺激因子的相关性

Study of correlation between glucocorticoid for lupus nephritis active role and renal B lymphocyte stimulator

目的探讨糖皮质激素(GC)对狼疮性肾炎(LN)患者活动性作用与肾内B淋巴细胞刺激因子(Bly S)的相关性。方法采用免疫组化法及ELISA法检测LN患者与健康体检者血清内及正常肾组织内的Bly S表达水平。结果 LN患者血清内及肾内Bly S表达水平高于正常对照者(P<0.05),GC治疗>4周组的LN患者肾内Bly S水平及SLE-DAI评分低于未经过GC治疗的LN患者,比较具有统计学意义(P<0.05)。结论 GC减轻LN患者疾病活动性的作用可能与GC降低LN患者肾内Bly S表达水平有密切关系。

Objective To study correlation between glucocorticoid for lupus nephritis active role and renal B lymphocyte stimulatorMethods Using immunohistoehemical and ELISA method to detect LN inpatients and healthy persons serum and expression levels of BlySin the normal kidney tissue. Results LN in serum samples from patients with renal and BLyS expression level is higher than that of normal controls （ P 〈 0. 05 ） , the treatment of GC 〉 4 weeks group of LN patients with renal levels of BLyS and SLE-DAI score lower than not after GC treatment of LN patients, with statistical significance （P 〈 0. 05 ）. Conclusions The role of GC in reducing disease activity in LN patients may be closely related to the decrease in BlyS expression in LN patients with GC.