子宫内膜癌组织脂联素和内脂素的表达及临床意义

ADIPONECTIN AND VISFATIN IN ENDOMETRIAL CARCINOMA: THEIR EXPRESSIONS AND CLINICAL SIGNIFICANCE

目的探讨脂联素和内脂素在子宫内膜癌组织表达及临床意义。方法采用免疫组织化学法检测36例正常子宫内膜、20例增生子宫内膜及40例子宫内膜癌组织中脂联素和内脂素的表达。结果在正常子宫内膜、增生子宫内膜和子宫内膜癌组织中,脂联素的阳性表达率逐渐降低,内脂素的阳性表达率逐渐升高,差异有统计学意义(χ2=13.427、9.244,P<0.05)。脂联素和内脂素在子宫内膜癌组织中的表达呈负相关(r=-0.666,P<0.05),二者的表达与肿瘤分化程度、临床分期、淋巴结转移及肌层浸润深度均无关(P>0.05)。结论脂联素和内脂素可能在子宫内膜癌的发生中发挥重要作用,二者表达呈负相关。脂联素和内脂素的检测可能有助于早期诊治子宫内膜癌。

Objective To investigate the expressions and clinical significance of adiponectin and visfatin in endometrial carcinoma（ EC）. Methods The expressions of adiponectin and visfatin in normal endometrium specimen（ n = 36）,in proliferative endometrium（ n = 20） and endometrial cancer tissue（ n = 40） were detected using immunohistochemistry method. Results According to the order of the normal endometrium,endometrium hyperplasia and EC,the positive expression rate of adiponectin gradually decreased（ χ~2= 13. 427,P〈 0. 05）,and the expression of visfatin gradually increased（ χ~2= 9. 244,P 〈 0. 05）. The expression of adiponectin and visfatin in EC tissue was negatively correlated（ r =-0.666,P 〈 0. 05）,and the expressions of the two parameters were not associated with the differentiation,clinical staging,lymph node metastasis and depth of muscular invasion（ P 〉 0. 05）. Conclusion Adiponectin and visfatin possibly play a significant role in occurrence of EC,the expression of these two markers shows negatively correlated. Their detection may help early diagnosis and treatment of this malignancy.