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DPP4抑制剂类药物治疗1型糖尿病的研究进展

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摘要 胰高血糖素样肽-1(GLP-1)是由肠道细胞分泌的激素,可以通过刺激胰岛素分泌、抑制胰高血糖素分泌、抑制胃排空和促进胰岛细胞增殖降低血糖。二肽基肽酶Ⅳ(DPP4)抑制剂能够抑制体内DPP4活性,防止其降解体内的GLP-1,是治疗糖尿病的新药。DPP4抑制剂类药物安全性、有效性、耐受性得到认可,临床上已广泛用于治疗2型糖尿病,但近来有观点认为,DPP4抑制剂也可用于1型糖尿病的治疗。本文主要就DPP4抑制剂作用机制及其在1型糖尿病治疗中的临床应用进行综述。
作者 王宾 李鑫德 杨乃龙
机构地区 青岛大学附属医院内分泌科 青岛大学附属医院痛风病重点实验室
出处 《齐鲁医学杂志》 2016年第3期376-378,共3页 Medical Journal of Qilu
关键词 抗原 CD26 蛋白酶抑制药 糖尿病 1型 治疗 综述
分类号 R587.105 [医药卫生—内分泌]
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参考文献35

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二级参考文献14

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齐鲁医学杂志
2016年 第3期

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