慢性牙周炎的氧化应激及抗氧化治疗研究进展

Oxidative stress and antioxitant therapy of chronic periodontitis

慢性牙周炎是一种由口腔常驻菌群失调引起的牙周组织慢性破坏性疾病.病原微生物是破坏牙周组织的始动因子,而机体免疫炎症反应也起到了重要作用.炎症状态下,牙周组织细胞产生过量的活性氧物质,超出机体代偿能力,形成氧化应激,通过促进炎症因子及破坏性酶等分泌的间接方式,或直接作用于生物大分子导致牙周组织损伤.抗氧化剂能够拮抗这一损伤作用,因此对慢性牙周炎具有潜在的治疗作用.本文将就过量活性氧物质对慢性牙周炎的作用以及抗氧化剂对牙周炎治疗效果的研究进展进行综述.

Chronic periodontitis is a progressive,infectious inflammation disease,caused by the dysbiosis of oral resident flora,leading to the destruction of periodontium.The onset of pathogenic microorganisms is the etiological factor of periodontitis,while the immuno-inflammatory response affects the progression of the disease.Under chronic periodontitis,oxidative stress occurs when excessive reactive oxygen species are produced and exceed the compensative capacity of the organism.Oxidative stress leads to the destruction of periodontium,in a direct way（damaging the biomolecule） or an indirect way（enhancing the produce of inflammatory cytokine and destructive enzymes）.Therefore,as the antagonist of the reactive oxygen species,antioxidants may be helpful to treat the chronic periodontitis.This paper reviewed relevant literatures about the destructive role of excessive reactive oxygen species and protective role of antioxidants in chronic periodontitis.