摘要
Dear Editor, The discovery that the mobile colistin resistance gene （mcr-1） is encoded by plasmids and is prevalent in food animals and human beings worldwide （Hasman et al., 2015; Liu et al., 2015） has challenged greatly our traditional idea that polymyxin （consisting of two isoforms：
Dear Editor,The discovery that the mobile colistin resistance gene(mcr-1)is encoded by plasmids and is prevalent in food animals and human beings worldwide(Hasman et al.,2015;Liu et al.,2015)has challenged greatly our traditional idea that polymyxin(consisting of two isoforms:polymyxin B and polymyxin E(colistin))acts as an ultimate line of refuge in the clinical treatment against the severe infections by the multidrug-resistant Gram-negative pathogens(Nation et al.,2015;Paterson and Harris,2015).To make
基金
supported by Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars (LR15H190001)
the National Natural Science Foundation of China (31570027)
the start-up package from Zhejiang University (Youjun Feng)
the "Young 1000 Talents" Award (Youjun Feng)
