食品用纸杯中光引发剂特定迁移量的气相色谱-串联质谱测定方法

Determination of the migration of photoinitiators from paper cup into food stimulants by gas chromatography-tandem mass spectrometry

目的建立11种光引发剂类化合物食品用纸杯特定迁移量的气相色谱-串联质谱（gas chromatographytandem mass spectrometry,GC-MS/MS）检测方法。方法食品模拟物中的光引发剂类化合物经反相固相萃取柱富集净化后,采用中等级性的DM-17MS气相色谱柱进行分离;采用三重四极质谱的多反应监测模式（multiple reaction monitoring,MRM）对化合物进行定量测定。结果本方法可在17 min内完成11种目标化合物的色谱分离。11种光引发剂在低、中、高3个添加水平的回收率在65.0%-119.8%范围内,相对标准偏差为1.2%-10.6%（n=6）,方法检出限为1-7μg/L,定量限为2-20μg/L。结论该方法灵敏度高,定量准确,适用于食品模拟物中光引发剂类物质特定迁移量的测定。

Objective To establish an analytical method for the determination of the migrants of 11 kinds of photoinitiator from paper cups into food simulants by gas chromatography-tandem mass spectrometric（GC-MS/MS）. Methods The reverse-phased solid phase extraction cartridges were used for the extraction, enrichment and clean-up of the 11 kinds of potoinitiator from simulants. The analytes were separated on a moderately polar DM-17 MS column, and subsequently determined by triple quadruple mass spectrometry operating under multiple reaction monitor（MRM） mode. Results The GC-MS/MS analysis was achieved within 17 min. The recoveries of the method were ranged from 65.0% to 119.8% for the 11 kinds of photoinitiator at 3 spiked levels, and the relative standard deviations were between 1.2% and 10.6%. The limits of detection（LOD） and the limits of quantification（LOQ） were 1-7 μg/L and 2-20 μg/L, respectively. Conclusion The established method has been validated to be sensitive and accurate, which is applicable to the analysis of migrants of photoinitiators in food simulants.