褪黑素受体信号通路在2型糖尿病中的作用

The role of melatonin receptor signal in type 2 diabetes

褪黑素是松果体分泌的激素,能调节包括睡眠在内的诸多生理过程。褪黑素通过与其受体特异性结合而在中枢和外周都发挥功能。胰腺β细胞中,褪黑素受体介导的信号通路可影响胰岛素的分泌以及β细胞的功能,并可通过提高5-羟色胺-N-乙酰基转移酶的活性来促进褪黑素的生成,而上调的褪黑素可抑制胰岛素的分泌,升高血糖。

Melatonin is a hormone secreted by the pineal gland and regulates many physiological conditions inclu- ding sleep. Melatonin specifically binds to melatonin receptors, regulating central and peripheral functions. The melatonin receptor-mediated signaling pathways in pancreatic β cell affect pancreatic insulin secretion and the func- tion of pancreatic β cell. The activation of melatonin receptors increases the arylalkylamine-N-acetyhransferase ac- tivity, which promotes secretion of melatonin, inhibit insulin secretion and increase blood sugar in circulation.