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长链非编码RNA与结直肠癌 被引量:2

Long non-coding RNA and colorectal cancer
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摘要 长链非编码RNA(lncRNA)是一类长度大于200 nt的非蛋白编码RNA分子,能同时与DNA、RNA和蛋白质分子相互作用,通过转录和转录后调控等多种作用机制在结直肠癌中发挥促癌或抑癌的双重作用。lncRNA表达异常或突变在结直肠癌的发生、发展、侵袭和转移过程中扮演着重要角色,且与患者预后密切相关。lncRNA有望为成为结直肠癌新的诊断和治疗靶点。 Long non-coding RNA (lncRNA, 〉 200 nt) can interact with DNA, RNA, protein molecules and/or their combinations, lneRNA is an essential regulator in transcriptional and post-transcriptional regulation and act as tumor promoter or suppresser in colorectal cancer. Misexpression or mutation of lneRNA plays an important role in cancer, development, invasion and metastasis and is closely related to patient's prognosis. So, lneRNA may be an important target for colorectal cancer diagnosis and treatment.
出处 《基础医学与临床》 CSCD 2016年第8期1159-1163,共5页 Basic and Clinical Medicine
关键词 长链非编码RNA 结直肠癌 long non-coding RNA colorectal cancer
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