摘要
(PCSK9 )BackgroundPro 蛋白质 convertase subtilisin/kexin 类型 9 是影响低密度的脂蛋白胆固醇(LDL-C ) 的血浆层次的分泌蛋白质。氧化 LDL 和织物因素(TF ) 贡献了 prothrombotic 状态的发展。探索在血浆之间的关系的现在的学习目的与冠的动脉疾病(CAD ) 在病人 PCSK9 和 TF 的铺平 .MethodsFrom 2013 年 7 月到 2014 年 3 月，我们注册了因为怀疑的 CAD，在这研究在北京 Anzhen 医院经历了冠的 angiography 的 197 个连续病人。所有病人没有使用类脂化合物阴沉的药的历史。这 197 个病人(131 男性和 66 女性，意味着年龄 56.9 ±；11.8 年) ， 81 angiographically 诊断了 CAD。临床的数据是镇定的。血浆 PCSK9 和 TF 用连接酶的 immunosorbent 试金(ELISA ) 被测量。血浆 PCSK9 和 TF 的层次被比较，他们的关联在 PCSK9 的不同耐心的 groups.ResultsBoth 血浆层次之中分析了(279.8 ±；60.4 µ； g/L 对 216.5 ±；45.3 µ； g/L， P <；0.01 ) 并且 TF (156.4 ±；26.6 µ； g/mL 对 112.1 ±；38.3 µ； g/L， P <；0.01 ) 在有 CAD 的病人是显著地更高的，作为与那些相比没有 CAD。关联分析证明 PCSK9 的血浆水平显著地有或没有 CAD 在两个病人与 TF 的被相关。然而，在调整以后的 multivariate 回归分析好久，性，吸烟，酒精，高血压和 hyperlipidemia 与类型 2 糖尿病 mellitus 仅仅在 CAD 病人显示出那，在 PCSK9 和 TF 的血浆层次之间有重要积极关联(β；= 0.353， P <；0.01 ) 没有糖尿病 mellitus， PCSK9 的 .ConclusionsThe 血浆水平独立地并且断然与糖尿病 mellitus 在 CAD 病人，然而并非在那些与 TF 的被联系。进一步的学习被需要调查内在的机制。
Background Pro-protein convertase subtilisin/kexin type 9 （PCSK9） is a secreted protein that influences plasma levels of low-density lipoprotein cholesterol （LDL-C）. Both oxidized LDL and tissue factor （TF） contributed to the development of prothrombofic state. The pre- sent study aims to explore the relationship between plasma level of PCSK9 and that of TF in patient with coronary artery disease （CAD）. Methods From July 2013 to March 2014, we enrolled 197 consecutive patients who underwent coronary angiography because of suspected CAD at Beijing Anzhen Hospital in this study. All patients had no history of using lipid-lowering medication. Of these 197 patients （1B 1 male and 66 female, mean age 56.9 ± 11.8 years）, 81 had angiographically diagnosed CAD. Clinical data were collected. Plasma PCSK9 and TF were measured using enzyme-linked immunosorbent assay （ELISA）. Levels of plasma PCSK9 and TF were compared and their correlation analyzed among different patient groups. Results Both plasma levels of PCSK9 （279.8 ± 60.4μg/L vs. 216.5 ± 45.3μg/L, P 〈 0.01） and TF （156.4 ± 26.6 μg/mL vs. 112.1 ± 38.3 μg/L, P 〈 0.01） were significantly higher in patients with CAD, as compared with those with- out CAD. Correlation analysis showed plasma level of PCSK9 was significantly correlated with that of TF in both patients with and without CAD. However, multivariate regression analysis after adjustment for age, gender, smoking, alcohol, hypertension and hyperlipidemia showed that only in CAD patients with type 2 diabetes mellitus, there was significant positive correlation between plasma levels of PCSK9 and TF （β = 0.353, P 〈 0.01）. Coneluslons The plasma level of PCSK9 is independently and positively associated with that of TF in CAD patients with diabetes mellitus, but not in those without diabetes mellitus. Further study is needed to investigate the underlying mechanism.
基金
This work was supported by National Natural Science Foundation of China （Grant No.81270380）.
