癫痫患儿认知学习能力与ERPP300关系探讨(附63例临床分析)

The correlation between ERP P300 value with the cognitive and learning status in epilepsy children

目的探析癫痫患儿的认知、学习状况以及事件相关电位(ERP)P300值的变化情况。方法分析2013年12月至2015年11月在我院就诊并经脑电图及临床确诊为癫痫的63例患儿(观察组)的临床资料。另外同期选取63例健康儿童作为本次研究的对照组。比较两组儿童的基线资料、ERP P300的潜伏期及波幅以及学习障碍筛查量表(PRS)的得分情况,并相关性分析ERP P300与PRS量表间的关系。结果两组儿童的基线资料无显著差异(P>0.05)。观察组患儿的ERP P300的潜伏期明显长于对照组(P<0.05),而两组间的P300波幅无显著差异(P>0.05)。观察组患儿的PRS量表非言语得分、言语得分以及总分均明显比对照组低(P<0.01)。观察组患儿的ERP P300潜伏期与PRS量表的非言语得分、言语得分、总分间均呈负相关性(P<0.05),而波幅与PRS量表各得分间无显著相关性(P>0.05)。结论癫痫患儿认知学习能力受损,ERP P300能以脑电形式较客观地对此类患儿认知学习情况进行及早反映。

Objective Our retrospective study was aimed to analyze the cognitive and learn- ing status of epilepsy children and the changes of ERP P300. Methods Clinical data of 63 cases of epilepsy children （observe group） received the diagnosis of EEG and clinical at our hospital from December,2013 to November,2015 was retrospectively analyzed. 63 healthy children at the same time were chosen as the control group in this research. The general information, the latency and amplitude of ERP P300 and the scores of PRS were compared. The relationship between ERP P300 and PRS was correlatively analyzed. Results The general information between two groups had no statistical difference （P〉0.05）. The latency of ERP P300 in observe group was longer than that in control group （P〈0.05） ,but amplitude of ERP P300 in two groups had no statistical difference （P〉0.05）. The non--verbal, verbal scores and total scores of PRS in observe group were all obviously higher than those in control group （P〈0.01）. The latency of ERP P300 in ob- serve group had negative correlation with non--verbal, verbal scores and total scores of PRS （P〈 0.05） ,but amplitude of ERP P300 had no correlation with PRS （P〉0.05）. Conclusion The abil- ity of cognitive and learning of epilepsy children is damaged. ERP P300 can objectively reflect the cognitive and learning of epilepsy status in form of EGG.