Galectin-1、Galectin-3、Galectin-9在宫颈鳞状细胞癌中的表达及其临床意义

Expression and clinical significance of Galectin-1,Galectin-3 and Galectin-9 protein in cervical squamous cell carcinoma

目的：探讨宫颈鳞状细胞癌组织中 Galectin-1、Galectin-3、Galectin-9蛋白的表达及其临床意义。方法选取宫颈鳞状细胞癌标本蜡块78例，采用免疫组织化学方法对宫颈鳞状细胞癌标本蜡块78例组织中的Galectin-1、Galectin-3和 Galectin-9蛋白表达进行检测，分析其表达与宫颈鳞状细胞癌临床病理特征的关系。结果 Galectin-1、Galectin-3在宫颈鳞状细胞癌组织中阳性表达率分别为89.7%、84.6%，均明显高于其正常宫颈组织中阳性表达率（12.8%、15.4%），差异均有统计学意义（P﹤0.05）；Galectin-9在宫颈鳞状细胞癌组织阳性表达率为17.9%，与正常宫颈组织Galectin-9阳性表达率（14.1%）比较差异未见统计学意义（P﹥0.05）。可以认为Ga-lectin-1、Galectin-3在宫颈鳞状细胞癌表达与组织学分级、临床FIGO分期、肌层浸润程度、淋巴结转移、宫外扩散有关，差异有统计学意义（P﹤0.05）；尚不能认为Galectin-9在宫颈鳞状细胞癌表达与组织学分级、临床FIGO分期、肌层浸润程度、淋巴结转移、宫外扩散相关，差异未见统计学意义（ P﹥0.05）。结论 Galectin-1、Galectin-3的高表达和Galectin-9的低表达在宫颈鳞状细胞癌的发生、发展中具有重要作用，对判断宫颈鳞状细胞癌患者的生物学行为具有一定的意义。

Objective To investigate the expression and clinical significance of Galectin-1 ,Ga-lectin-3 and Galectin-9 protein in cervical squamous cell carcinoma. Methods Selected 78 cases of cer-vical squamous cell carcinoma specimens of paraffin,using immunohistochemical method to detect the ex-pression of 78 cases of Galectin-1 ,Galectin-3 and Galectin-9 in plasma cervical squamous cell carcinoma＆amp;nbsp;specimens of paraffin blocks,and analyzed the correlation between the expression and the clinical features of cervical squamous cell carcinoma. Results The positive expression rates of Galectin-1 and Galectin-3 in cervical squamous cell carcinoma tissue was 89. 7% and 84.6% respectively,and they were significantly higher than those in normal cervical tissue（ 12.8% and 15.4%）,the differences were statistically significant（ P﹤0.05 ）;the positive expression rate of Galectin-9 in cervical squamous cell carcinoma tissue was 17.9%,and that in normal cervical tissues was 14. 1%,there was no statisti-cal significance（ P﹥0.05 ）. The expression of Galectin-1 and Galectin-3 in cervical squamous cell car-cinoma were all related with histological grade,FIGO clinical stage,myometrial infiltration,lymph node metastasis,extrauterine spread,and the differences were statistically significant（all P﹤0.05）;The ex-pression of Galectin-9 in cervical squamous cell carcinoma had no specific correlation with histological grade,FIGO clinical stage,myometrial infiltration,lymph node metastasis,extrauterine spread,the differences were not statistically significant（ P﹥0.05 ）. Conclusions The high expression of Galectin-1 and Galectin-3 and low expression of Galectin-9 have important role in the occurrence and development of squamous cell carcinoma of the cervix,and they have a certain significance in judging the biological be-havior of cervical squamous cell carcinoma.