糖尿病合并牙周病牙周基础治疗对龈沟液中MMP-3的影响

Patients with diabetes mellitus and periodontitis periodontal basic treatment of matrix metalloproteinases in gingiva groove liquid- 3impact study

目的:探讨2型糖尿病(DM)合并牙周病时牙周基础治疗对病人龈沟液中基质金属蛋白酶-3(MMP-3)的含量、牙周炎症变化以及对血糖控制的影响。方法 :选择2型糖尿病合并牙周病(DMCP)患者和单纯慢性牙周炎(CP)患者各30例,行牙周基础治疗。在治疗前、治疗后2个月和4个月记录所有患者牙周临床指数,并检测血清中糖化血红蛋白(HbAlc)及龈沟液中MMP-3含量。结果:各组内探诊深度(PD)和菌斑指数(PLI)治疗后2个月和4个月相比治疗前显著降低,而附着丧失(AL)仅在治疗后4个月显著降低(P<0.05),DMCP组与CP组MMP-3含量在治疗后2个月及4个月与治疗前相比均有统计学意义,DMCP组和CP组仅在治疗前MMP-3含量差异有统计学意义,而治疗后无明显区别。治疗后4个月HbAlc含量水平显著降低(P<0.05)。DMCP组和CP组治疗前MMP-3含量与牙周临床指标以及HbAlc含量呈正相关。结论:牙周基础治疗可以帮助DMCP患者控制血糖、改善牙周健康状态。

Objective：Research periodontal basic treatment for diabetes patients with periodontitis with gingival sulcus of matrix metalloproteinases-3content in the liquid,periodontal inflammation change and influence on blood sugar control.Methods：Choosed DMCP chronic periodontitis patients and pure（chronic periodontitis,CP）all 30 patients with routine periodontal basic treatment,before and after treatment for 2months and 4months record all patients periodontal clinical indices,and detection of serum glycated hemoglobin（HbAlc）and the gingival sulcus MMP-3content in the liquid.Results：after treatment,the concentration in each group（PD,PLI,AL）of MMP-3were significantly reduced（P〈0.05）,and the concentration of HbAlc reduced significantly 4months after treatment（P〈0.05）.The MMP-3level was correlated with clinical periodontal parameters and HbAlc level before treatment in both groups.Conclusion：The basic periodontal therapy is effective in the control of blood glucose level,improvement of clinical periodontal parameters and decrease of MMP-3level in DMCP patients.