粪钙卫蛋白和乳铁蛋白检测在诊断溃疡性结肠炎中的临床意义

Clinical significance of fecal calprotectin and lactoferrin in patients with ulcerative colitis

目的:研究粪钙卫蛋白和乳铁蛋白在诊断溃疡性结肠炎中的表达水平及临床诊断价值。方法:收集溃疡性结肠炎患者63例和健康对照43例,采用ELISA方法测定粪便中粪钙卫蛋白和乳铁蛋白,并进行统计学分析。结果:溃疡性结肠炎患者钙卫蛋白含量明显高于健康对照组(P<0.01),且随活动期级别增高,粪钙卫蛋白的水平逐渐增高(P<0.05)。溃疡性结肠炎患者乳铁蛋白含量明显高于健康对照组(P<0.01),随活动期级别增高,粪钙卫蛋白的水平逐渐增高(P<0.05)。乳铁蛋白(r=0.71,P<0.01)和钙卫蛋白(r=0.79,P<0.01)含量均与肠镜分级结果显著相关。结论:粪便中钙卫蛋白和乳铁蛋白在评价溃疡性结肠炎具有一定的临床意义。

Objective：To evaluate the expression and clinical diagnostic value of fecal calprotection and lactoferrin in patients with ulcerative colitis.Methods：63patients with ulcerative colitis and 43 healthy controls were enrolled from our hospital.The concentrations of calprotectin and lactoferrin in fecal was measured by ELISA assay and analyzed statistically.Results：The expression of fecal calprotection in ulcerative colitis patients was higher than that in healthy controls（P0.01）,with the increase of active grade of ulcerative colitis,the level of fecal calprotection gradually increased（P0.05）.The protein of lactoferrin was increased in ulcerative colitis patients（P0.01）,with the increase of active grade of ulcerative colitis,the level of fecal lactoferrin gradually increased（P0.05）.Levels of fecal lactoferrin（r=0.71,P0.01）and calprotection（r=0.79,P0.01）in active grade group were significantly related to histological grade under colonoscopy.Conclusion：Fecal calprotection and lactoferrin helped to evaluate the ulcerative colitis.