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盐酸沙格雷酯降解杂质的制备 被引量：1

Synthesis of impurity of sarpogrelate hydrochloride
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摘要 目的合成盐酸沙格雷酯杂质Ⅲ。方法以2-[2-(3-甲氧基苯基)乙烯基]苯酚为原料,经过亲核取代、加成、酰化、环氧化、还原等5步反应制备盐酸沙格雷酯杂质Ⅲ。结果用廉价原料合成了盐酸沙格雷酯杂质Ⅲ,总收率30%。结论该工艺简单可行,产品质量符合对照品要求。 Objective To synthesize impurity III of the sarpogrelate hydrochloride. Methods The impurity III of the sarpogrelate hydrochloride was synthesized with 2-[2-（3-methoxyphenyl） vinyl] phenol by substitution reaction, addition reaction, acylation reaction, epoxidation reaction. Results The impurity III of sarpogrelate hydrochloride was synthesized with inexpensive and readily available catalyst and the total yield of the target compound was 30%. Conclusion This technology is simple, possible and the quality of the produce meets the national standard.
作者 张建礼 孔令金 李宗涛 张涛
机构地区 山东齐都药业有限公司
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2016年第7期538-540,共3页 Chinese Journal of Antibiotics
关键词 盐酸沙格雷酯 杂质 抗血栓 Sarpogrelate hydrochloride Impurity Antithrombotic
分类号 R9 [医药卫生—药学]
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参考文献8

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二级参考文献8

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中国抗生素杂志
2016年 第7期

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