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C1q/肿瘤坏死因子相关蛋白12的研究进展 被引量：4

Recent Progress in C1q/Tumor Necrosis Factor-related Protein 12
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摘要 C1q/肿瘤坏死因子相关蛋白12(CTRP12)是近年新发现的一种与脂联素高度同源的脂肪因子,主要作用于脂肪组织和肝脏。CTRP12可分别通过增强胰岛素信号和直接激活磷脂酰肌醇3-激酶-蛋白激酶B(PI3K-Akt)信号通路抑制糖异生、促进葡萄糖摄取的方式调节全身糖代谢发挥抗糖尿病作用;CTRP12还可通过抑制巨噬细胞的炎症反应发挥非特异性抗炎作用;另外CTRP12可能有刺激胰岛β细胞促进胰岛素分泌的作用。 C 1 q/tumor necrosis factor-related protein 12 （ CTRPI 2 ） , a newly identified adipokine, is a paralog of adiponectin. It acts mainly on fat tissue and liver. CTRP12 may improve insulin sensitivity by enhancing insulin signaling and directly activating the phosphatidylinositol 3 kinase-protein kinase B （PI3 K- Akt） signaling pathway to suppress gluconeogenesis and promote glucose uptake;CTRP12 may exert an non- specific anti-inflammatory effect by inhibiting the inflammatory response of maerophages. In addition to, CTRP12 is possible to stimulate the pancreatic 13 cells to increase insulin secretion.
作者 张敏 吴晨光
机构地区 江苏大学附属人民医院内分泌科
出处 《医学综述》 2016年第14期2762-2765,共4页 Medical Recapitulate
关键词 C1q/肿瘤坏死因子相关蛋白12 肥胖 胰岛素抵抗 炎症 CI q/tumor necrosis factor-related protein 12 Obesity Insulin resistance Inflammation
分类号 R58 [医药卫生—内分泌]
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参考文献23

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医学综述
2016年 第14期

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