摘要
目的观察卡前列素氨丁三醇注射液治疗妊娠产后出血的临床疗效及不良反应。方法 76例产后出血患者随机分为对照组38例与试验组38例。对照组阴道分娩患者于分娩后肌内注射缩宫素注射液20 U,剖宫产患者于分娩后宫体注射缩宫素注射液20 U;试验组阴道分娩患者于分娩后肌内注射卡前列素氨丁三醇注射液250μg,剖宫产患者于分娩后宫体注射卡前列素氨丁三醇注射液250μg。比较2组的临床疗效、治疗前后血清一氧化氮(NO)、一氧化氮合酶(NOS)、脑钠素(BNP)水平以及不良反应发生情况。结果治疗后,对照组临床总有效率为78.95%,显著低于试验组的94.74%(P<0.05)。2组治疗后血清NO、NOS、BNP水平均显著降低,且试验组显著低于对照组(P<0.05)。对照组不良反应发生率为10.53%,试验组为7.89%,差异无统计学意义(P>0.05)。结论卡前列素氨丁三醇注射液治疗妊娠产后出血的临床疗效显著,安全性高。
Objective To evaluate the clinical efficacy and safety of carboprost tromethamine injection in the treatment of postpartum hemorrhage of pregnancy. Methods A total of 76 cases with postpartum hemorrhage of pregnancy were dividing into control group and treatment group with each 38 cases. After delivery,vaginal delivery patients in control group were given oxytocin injection 20 U by intramuscular injection,cesarean section after delivery in control group were given oxytocin injection20 U by intravenous drip. Vaginal delivery after delivery in treatment group were given carboprost tromethamine injection 250 μg by intramuscular injection. Cesarean section after delivery in treatment group were given carboprost tromethamine 250 μg intravenous drip. The clinical efficacy,nitric oxide( NO),nitric oxide synthase( NOS),brain natriuretic peptide( BNP) and adverse drug reactions were compared between the two groups. Results The clinical efficacy in treatment group was94. 74%,significantly higher than 78. 95% in control group( P〈0. 05).The serum levels of NO,NOS and BNP were decreased after treatment with treatment group much lower than control group( 10. 53 vs 7. 89%,P〈0. 05).The adverse drug reactions was not statistically different between the two groups( 10. 53 vs 7. 89%, P〈0. 05). Conclusion Carboprost tromethamine injection in treatment of postpartum hemorrhage of pregnancy was effective with high safety.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2016年第13期1182-1184,共3页
The Chinese Journal of Clinical Pharmacology
关键词
卡前列素氨丁三醇注射液
妊娠产后出血
一氧化氮合酶
脑钠素
carboprost tromethamine injection
postpartum hemorrhage
nitric oxide synthase
brain natriuretic peptide