宫颈脱落细胞检查联合人乳头瘤病毒检测对诊断宫颈癌的临床意义

Clinical significance of cervical liquid based cytology combined with human papilloma virus detection in the diagnosis of cervical cancer

目的探讨宫颈脱落液基细胞学检查(TCT)联合人乳头瘤病毒检测(HPV-DNA)诊断宫颈癌的临床意义。方法选取2012年5月至2015年5月间海南省文昌市人民医院收治的100例宫颈癌患者,分别单独行TCT检测、单独HPV-DNA检测、HPV-DNA+TCT检测,比较3种检测方法的诊断结果。结果 HPV-DNA+TCT检测宫颈癌的阳性率为81.0%,显著高于单独TCT检测的51.0%和单独HPV-DNA检测的55.0%,差异有统计学意义(P<0.05);单独TCT与单独HPV-DNA检测的阳性率间差异无统计学意义(P>0.05)。结论 TCT和HPV-DNA联合诊断宫颈癌阳性符合率较高,具有显著的临床应用价值。

Objective To explore the clinical significance of cervical liquid based cytology （TCT） combined with human papilloma virus detection （HPV-DNA） in the diagnosis of cervical cancer. Methods From May 2012 to May 2015 in Wenehang People＇s Hospital, 100 cervical cancer patients were enrolled in the study. TCT and HPV-DNA were made and the diagnostic value was evaluated. Results The positive rate of HPV-DNA ＋ TCT detection in cervical cancer was 81.0%, significantly higher than that of pure TCT detection （51.0%） and HPV-DNA detection （55.0%）, with significant differences （ P 〈 0. 05 ）. There was no significant differences in positive rate of pure TCT and HPV-DNA detection （ P 〉 0.05 ）. Conclusion The positive rate of TCT combined with HPV-DNA in the diagnosis of in the diagnosis of cervical cancer is higher. And it has significant clinical value.